Hemodynamical changes in patients with pulmonary hypertension


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Title Hemodynamical changes in patients with pulmonary hypertension
Period 03 / 2002 - 03 / 2005
Status Completed
Research number OND1286792


Pulmonary hypertension is a rare, progressive and often fatal disease, for which the therapeutic options are limited. The study of pulmonary hypertension and the evaluation of new therapeutics have been hindered until now by a lack of a quantitative description of the cardiac and pulmonary circulation. The purpose of our study will be to identify the quantitative effects of the principal cardiac and pulmonary vascular variables involved in the development of pulmonary hypertension making it possible to direct new therapeutical strategies by means of a rational approach. Therefore, we use a mathematical model based on flow and pressure wave analysis. Flow waves in the pulmonary artery are measured by means of MRI whereas pressure waves are measured by means of right heart catherisation. After assessing the validity of the model, the clinical value of this model-based approach will be studied with special focus on the differential diagnosis of pulmonary hypertension and in the study the effects of new therapeutics.

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Researcher Dr. A. Boonstra
Researcher J.W. Lankhaar
Researcher Dr. J.T. (Tim) Marcus
Researcher Dr. R.J. Roeleveld
Researcher Dr. H.J. Smit
Project leader Prof.dr. R.M. Heethaar
Project leader Prof.dr. P.E. Postmus
Project leader Prof.dr. A. Vonk Noordegraaf
Project leader Prof.dr. N. Westerhof


D21200 Biophysics, clinical physics
D21700 Physiology
D23220 Internal medicine

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