This program includes research in the fields of genetic epidemiology and endocrinologic epidemiology. Genetic epidemiologic research aims at quantifying the population risk of disorders associated with genetic risk factors and at identifying new genetic factors involved in complex genetic disorders. For the empirical studies the emphasis is on neurodegenerative and neurovascular disorders. The work in endocrinological epidemiology focuses on the question whether circulating hormone levels are associated with incident diseases of the elderly and with parameters of frailty. The emphasis is on determinants of locomotor diseases (osteoporosis, osteoarthritis) and on sex hormones and thyroid hormones as determinants of disease.