The major research area within Research Line 1 ?Metabolic Syndrome? are studies on the effects of lifestyle (diet and physical activity, health promotion) on metabolism under normal and ?stressed? (chronic metabolic stress) conditions. Research is concentrated around two complementary, but interacting research programmes: 1. Energy balance and obesity 2. Diabetes and cardiovascular disease risk. The focus is on the powerful interplay between life-style, metabolic alterations, and chronic diseases such as obesity, diabetes type 2 mellitus, and cardiovascular diseases. The mission of the research line is to identify, understand, and characterize physiological and functional changes in selected tissues related to the metabolic syndrome, and to develop and implement life-style based (diet, physical activity) interventions that will prevent the development of the metabolic syndrome. We strive to be a leader in the area of research that integrates approaches from the molecular to the whole body and population level. Our ultimate goal is to translate our findings into new science-based life-style interventions.