| This research involves the study of the significance of neurohumoral factors in the process leading to heart failure; hormone status in the ageing female is included. Skeletal muscle is also subject of study in so far as the investigations contribute to the elucidation of questions which skeletal and cardiac muscles have in common. Skeletal muscle function is also studied in heart failure in both patients and in experimental animals with the purpose to improve total body function in heart failure patients. Our interest in the mechanisms which lead to failure in muscle function can further be subdivided in 'acute failure' studies and 'chronic failure' studies; examples of this are reperfusion injury studies and pathological hypertrophy studies, respectively. |
