| This research aims at development of polymer nanoparticles having imprints of membrane proteins on their surface. Such an imprint is a shape complementary to the protein template, having functional groups positioned such that they interact with the template. It would allow selective and reversible binding of the protein of interest and would open up a wide range of applications such as: protein recognition for analysis, protein purification, diagnostics, or drug delivery. Membrane proteins are particularly interesting because they serve many biological functions and are often the therapeutic targets to treat a variety of diseases. We will focus on the preparation of degradable particles which will bind to membrane proteins in specific cells, tissues, or microorganisms, aiming at a new generation of drug carriers which display unprecedented intrinsic targeting properties. Besides, the particles may act as a drug themselves, since they may be capable of blocking imprinted membrane receptors or inhibit proliferation of bacteria or viruses. Finally, the particles can be a favorable substitute for monoclonal antibodies in a variety of applications, having the advantages of being cheaper, more stable, non-immunogenic, and re-usable. |
