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Calciumopname, vitamine D status en het risico op diabetes mellitus type 2

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Titel Calciumopname, vitamine D status en het risico op diabetes mellitus type 2
Looptijd 12 / 2003 - 04 / 2007
Status Afgesloten
Onderzoeknummer OND1302670
Leverancier gegevens Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)

Samenvatting (EN)

- Background: Poor vitamin D status is highly prevalent in the Netherlands, particularly among ethnic minorities and the elderly. Both calcium intake and vitamin D status are required for normal insulin secretion and affect parathyroid hormone (PTH) concentrations. High PTH concentrations may reduce insulin sensitivity. - Study objectives: To test the hypothesis that (1) Low calcium intake and poor vitamin D status are associated with type 2 diabetes in the elderly. (2) Calcium intake and vitamin D status affect insulin sensitivity and insulin secretion, and these effects are mediated by concentrations of PTH and 1,25-OH vitamin D. (3) Vitamin D status is associated with hyperglycemia in ethnic minority groups, and vitamin D suppletion can improve glucose metabolism in those with poor vitamin D status. - Approach: To test hypotheses 1 and 2, we will use data from the Hoorn Study. We will study the important steps of the putative causal chain: diet (dietary patterns, calcium and vitamin D intake), vitamin D status, hormones (PTH, 1,25-OH vitamin D), intermediary traits (parameters of insulin sensitivity and secretion), and type 2 diabetes. The association with type 2 diabetes will also be examined in the Longitudinal Aging Study Amsterdam (LASA). For the 3rd hypothesis, we will study vitamin D status in relation to fasting plasma glucose in a cross-sectional study of vitamin D status in 6 ethnic groups, and examine whether vitamin D status partly explains ethnic differences in hyperglycemia. In a subgroup with poor vitamin D status, we will conduct a trial of vitamin D suppletion and hyperglycemia. - Expected results: This study may provide more insight into the role of calcium, vitamin D, and related hormones on the development of type 2 diabetes, and may provide new clues for public health action to reduce the burden of type 2 diabetes in the elderly and ethnic minority groups.

Betrokken organisaties

Betrokken personen

Projectleider Dr.ir. R.M. van Dam

Classificatie

A71000 Voeding
A73000 Eerstelijnsgezondheidszorg en tweedelijnsgezondheidszorg
A75000 Gezondheidsvoorlichting
D21300 Biochemie
D21700 Fysiologie
D24200 Preventieve gezondheidszorg, GVO

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