TREND (Trauma-RElated Neuronal Dysfunction)


Update content

Title TREND (Trauma-RElated Neuronal Dysfunction)
Period 03 / 2004 - 03 / 2008
Status Completed
Research number OND1309144


A consortium of academic hospitals, technical research groups and commercial companies has initiated a major research programme in the area of clinical neurology named Trauma-RElated Neuronal Dysfunction (TREND) . The programme will explore novel assessment technologies for the evaluation of patients suffering from Complex Regional Pain Syndrome (CRPS). Complex Regional Pain Syndrome (CRPS), formerly known as Reflex Sympathetic Dystrophy, is a common, disabling and poorly understood disorder that predominantly affects female Caucasians and frequently follows an injury or surgery. It is mainly known for its sensory and autonomic symptoms and signs including pain, swelling, and changes of the color, temperature and sweating of the skin, features that are typical of inflammation. More recently, the clinical spectrum has been broadened to include movement disorders (weakness, dystonia, tremor and jerks) that seem to increase in frequency as the disease duration lengthens. The yearly incidence of CRPS in the Netherlands is estimated at 45 per 100.000. CRPS, however, does not stand alone. Repetitive Strain Injury (RSI), Fibromyalgia and Whiplash Syndrome share many aspects with CRPS, including the spectrum of clinical sensory, autonomic and motor features, the high female predominance and the variable extent in which trauma may provoke the onset of these syndromes. The clinical and demographic denominators of these Trauma-Induced Syndromes (TIS) suggest that these disorders may evolve through a common pathway and support the notion that CRPS may stand as an explanatory model for this group. Because these syndromes have a poor responsiveness to conventional treatment modalities they decrease people s quality of life, impinge on work or recreational activities, increase healthcare resource utilization, and given their large prevalence, have a major socio-economic impact on society. Given the importance of both peripheral and central neuronal dysfunction in the pathogenesis of CRPS, the consortium s name is Trauma RElated Neuronal Dysfunction (TREND). The consortium will integrate research on epidemiology, assessment technologies, pharmacotherapeutics, proteomics, and genetics on CRPS. It will address the following aims: * Assess the occurrence of CRPS in the general population and study its disease course. * Develop concepts on the intrinsic and extrinsic factors that play a role in the development of acute and chronic phase of CRPS. * Develop reliable and valid assessment technologies for the evaluation of CRPS patients, using the latest computer vision and signal analysis techniques. * Develop effective treatments for early CRPS with the aim of intervening to prevent the occurrence of a chronic course. * Develop effective treatments for chronic CRPS to minimize the impairments and disabilities that could arise from incurable disease. National partnership The consortium consists of seven Dutch universities and two commercial companies: * Leiden University Medical Center (Departments of Neurology, Anesthesiology and Genetics) * Delft University of Technology (Man-Machine Systems & Control group) * Academic Hospital Groningen (Department of Rehabilitation) * Academic Hospital Maastricht (Department of Anesthesiology) * Erasmus University Medical Center (Department of Anesthesiology, Institute of Medical Information) * Utrecht University (Department of Biomolecular Mass Spectrometry) * Vrije Universiteit Amsterdam (Department of Anesthesiology) * FCS Control Systems, a specialist in mechatronics for medical applications * Noldus Information Technology, an innovative developer of software and instrumentation for the study of behavior and movement.

Related organisations

Related people

Project leader Prof.dr. J.J. van Hilten


D23210 Dermatology, venereology, rheumatology, orthopaedics
D23230 Neurology, otorhinolaryngology, opthalmology
D25000 Kinesiology

Go to page top
Go back to contents
Go back to site navigation