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RACE II (RAte Control Efficacy in permanent atrial fibrillation)

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Title RACE II (RAte Control Efficacy in permanent atrial fibrillation)
Period 10 / 2004 - 10 / 2007
Status Completed
Research number OND1309804
Data Supplier Website ICIN

Abstract

Study design: A multi-center randomized open label study, comparing two treatment strategies. 38 centers in Netherlands will participate. Patients will be randomized to strict (heart-rate below 80 bpm) or lenient rate control (heart rate below 80 bpm) . Study objectives: 1. To show that lenient rate control is not inferior to strict rate control in terms of cardiovascular mortality and morbidity 2. To show that lenient rate control is not inferior to strict rate control in terms of all cause mortality, cardiovascular hospitalizations, NYHA class for exercise tolerance, left ventricular function and left atrial size, quality of life, neurohormonal activation as measured by NT-proBNP, hospitalization for heart failure, syncope, sustained ventricular tachycardia, appropriate shocks or anti-tachycardia pacing of ICD for ventricular arrhythmias, cardiac arrest, and pacemaker implantations, stroke, systemic emboli, and bleeding, unstable angina pectoris and myocardial infarction, costs and renal function

Related organisations

Related people

Researcher Drs. M. Volbeda
Project leader Prof.dr. M.P. van den Berg
Project leader Prof.dr. I.C. van Gelder

Classification

A76000 Patients care
D23220 Internal medicine

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