Discovery of novel circadian clock components in light signaling pathways
02 / 2005 - unknown
The circadian clock regulates processes from gene expression to behaviour, such that activity is characteristic according to time of day. Neurospora crassa is considered a simple genetic model system for investigations into clock mechanisms and components. In Neurospora, clock components are part of light input pathways (WHITE COLLAR-1 is both a clock component and a blue light photoreceptor). Furthermore, there is evidence for more complex light signaling mechanisms and the Neurospora genome sequence indicates additional photoreceptor candidates. Novel light regulated processes will be identified, and their regulation by novel Neurospora photoreceptors will be determined. The relationship of these processes to clock regulation will be assessed to find novel clock components and mechanisms.