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Visualising cellular pathways during the interaction of intestinal...

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Title Visualising cellular pathways during the interaction of intestinal epithelial cells and lactic acid bacteria
Period 02 / 2006 - 05 / 2008
Status Completed
Research number OND1313403
Data Supplier Centrum voor Moleculaire en Biomoleculaire Informatica - CMBI

Abstract

Intestinal epithelial cells of the intestines undergo apoptosis (a form of programmed cell death) as a regular part of their life cycle. Apoptosis of senescing cells leads to a rejuvenation of the intestinal wall and leads to improved functioning of the intestines. Some lactic acid bacteria may induce an acceleration of this process, such that a suboptimal intestinal functioning can be improved. The interaction of bacteria and epithelium will be visualised as well as possible using bioinformatics, transcriptomics and proteomics.

Abstract (NL)

Darmepitheelcellen ondergaan apoptose (een vorm van geprogrammeerde celdood) als een normaal onderdeel van de levenscyclus. Apoptose van oudere cellen maakt verjonging van de darmwand mogelijk en leidt tot een betere darmfunctie. Sommige melkzuurbacteriƫn kunnen dit proces zodanig versnellen dat een suboptimale darmwerking verbeterd kan worden. Via bioinformatica, transcriptomics en proteomics technieken zal deze interactie zo goed mogelijk in kaart worden gebracht.

Related organisations

Related people

Researcher Dr.ir. P. van Baarlen
Project leader Prof.dr. M. Kleerebezem
Project leader Prof.dr. R.J. Siezen

Classification

A70000 Public health and health care
D21100 Bioinformatics, biomathematics, biomechanics
D21500 Histology, cell biology
D22100 Microbiology
D23220 Internal medicine

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