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Neural stem cells in the combat against brain tumors

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Title Neural stem cells in the combat against brain tumors
Period 12 / 2005 - 12 / 2009
Status Completed
Dissertation Yes
URL http://www.rug.nl/umcg/faculteit/disciplinegroepen/neurowetenschappen/PhDprojectsMedPhysiol/vdMeulen
Research number OND1316455
Data Supplier Website BCN; Website UMCG

Abstract

The dismal prognosis for patients with Glioblastoma Multiforme asks for new treatment modalities that circumvent the problems of the Blood Brain Barrier, the heterogeneity of the tumour cells, and their extensive infiltrative nature. Such treatment options may consist of more specific targeting of drugs and better delivery techniques. It has been shown that Neural Stem Cells (NSCs) can migrate towards a intracerebral tumour in vivo and have the capacity to track infiltrating tumour cells. Their migratory capacities make NSCs promising delivery vehicles in the therapy of brain tumours. The use of NSCs as killing messengers , which can deliver tumour attacking compounds, has been investigated intensively in the last few years. New findings indicate that NSCs might not only serve as magic bullets that can be loaded with tumour killing agents, they seem to have the intrinsic capacity to restrain tumour growth. NSCs might thus be endogenous inhibitors of tumour development. However, it is yet not clear how NSCs inhibit the growth of tumour cells. Two general possibilities might be important here. First NSCs need to be in direct contact with the tumour, thus cell-cell contact is needed, or second NSC`s might release substances with tumour-growth inhibiting capacities. We observed that NSC conditioned media clearly diminished the growth of glioblastoma tumour cells. These results suggest the presence of substance that affects tumour cells in conditioned media, which indicates that NSCs produce and release a substance which affects the growth of tumour cells. Our aim is to further elucidate the growth inhibitory capacities of NSCs. Additionally, the nature of the substance responsible for the growth inhibitory effect will be investigated. Used techniques are Flow Cytometry, Immunocytochemistry, Cell vialbility assays, Proteomics and Functional Genomics approaches.

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Classification

A73200 Second-line health care
D21500 Histology, cell biology
D23120 Oncology
D23230 Neurology, otorhinolaryngology, opthalmology

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