Research

Genetic disorders of HDL metabolism: from model to mechanism

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Title	Genetic disorders of HDL metabolism: from model to mechanism
Period	01 / 2008 - 06 / 2011
Status	Completed
Dissertation	Yes
Research number	OND1321648
Data Supplier	NWO

Abstract

We hypothesize that HDL protects against coronary artery disease (CAD) primarily through acting as an anti-inflammatory modality. It is proposed to investigate the association between inflammation and HDL function in inflammatory and cardiovascular diseases.

Abstract (NL)

Mensen met een hoog HDL-cholesterol in het bloed lopen minder kans op hart- en vaatziekten. Onno Holleboom ontdekte twee enzymen, LCAT en ppGaINAc-T2, die een belangrijke rol spelen in het HDL-metabolisme. Zij vormen daardoor potentiële aangrijpingspunten voor toekomstige therapieën.

Related organisations

Secretariat	Division of Vascular Medicine (UvA)
Financier	Netherlands Organization for Scientific Research (NWO)

Related people

Supervisor	Prof.dr. J.J.P. Kastelein
Supervisor	Prof.dr. E.S.G. Stroes
Doctoral/PhD student	Dr. A.G. Holleboom

Classification

D21700	Physiology
D23110	Infections, parasitology
D23220	Internal medicine