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Immunoglobulin A and neutrophil immunoglobulin A Fc receptor (Fc-alpha-RI)...

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Title Immunoglobulin A and neutrophil immunoglobulin A Fc receptor (Fc-alpha-RI) in mucosal infections
Period 01 / 2013 - unknown
Status Current
Research number OND1323250
Data Supplier VUmc CCA

Abstract

Immunoglobulin A (IgA) is the principal antibody in mucosal areas and plays a key role in mucosal defense. We have demonstrated that the Fc receptor for IgA (Fc-alpha-RI) is the most potent Fc receptor that triggers neutrophil activation. This led to phagocytosis of bacteria, such as E. coli, S. aureus and Salmonella. Moreover, release of neutrophil extracellular traps was observed, which can result in capture of extracellular bacteria in vitro. Currently, we are investigating which role IgA and Fc-alpha-RI play in mucosal infections. We have created a transgenic mouse model, and established a Salmonella infection model. This will enable us to investigate the importance of Fc-alpha- RI and IgA in vivo. The aim of this projecture is therefore to unravel the role of Fc-alpha-RI and IgA on neutrophils in innate and acquired immunity in more detail.

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Related people

Project leader Dr. M. van Egmond

Classification

D21800 Immunology, serology
D23220 Internal medicine

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