In this project we study the etiology of tendinosis. Our in-vitro differentiation studies showed that tendon-derived cells have multilineage potential. For example, this picture shows human tendon cells that were able to form lipid vacuoles. We want to demonstrate that similar differentiation processes play a role in the development of tendinosis. This in-vitro culture model for tendinosis can then be used to find and evaluate (new) therapeutical agents.