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Bicaudal-D: Switching Motors, Cargo and Direction

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Title Bicaudal-D: Switching Motors, Cargo and Direction
Period 07 / 2007 - 03 / 2010
Status Completed
Dissertation Yes
Research number OND1325555
Data Supplier Website EMC

Abstract

Microtubules are cytoskeletal elements, which serve as rails for intracellular transport. We are interested in how the organisation of microtubule network is controlled and how the motility of different cargos is regulated. Our research is focused on microtubule plus end tracking proteins (+TIPs) - a group of microtubule-associated factors, which bind specifically to the tips of growing microtubules. We investigate how these proteins regulate microtubule dynamics and microtubule association with various cellular structures. We also study the mechanisms of targeting of microtubule-based motors to membrane organelles and the signalling pathways, which control motor activity.

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Related people

Supervisor Prof.dr. F.G. Grosveld
Co-supervisor Prof.dr. A.S. Akhmanova
Researcher Dr. I. Grigorev
Researcher Dr. S. Montenegro Gouveia
Doctoral/PhD student Dr. G.D. Splinter

Classification

D21300 Biochemistry
D21500 Histology, cell biology
D21700 Physiology

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