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Production of therapeutic proteins in mushroom

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Title Production of therapeutic proteins in mushroom
Period 10 / 2007 - 03 / 2010
Status Completed
URL http://www.stw.nl/Projecten/U/ufa/ufa7787.htm
Research number OND1325930
Data Supplier Website STW

Abstract

Most of the therapeutic proteins (e.g. antibodies and hormones) are proteins that are secreted by human cells via the secretory pathway. Many of these therapeutic proteins are glycosylated during passage through this pathway and the glycans on the protein often play a crucial role in their pharmacological properties. At the moment, therapeutic proteins are produced in mammal cell lines. Construction of these lines is complex and culturing expensive. Mushroom forming basidiomycetes are interesting candidates for the efficient production of therapeutic glycoproteins. They have a glycosylation pattern which is more similar to that of humans than that of plants and other fungi. Within this project we will improve heterologous protein production in mushroom and will further humanize its glycosylation machinery.

Related organisations

Related people

Project leader Dr. L.G. Lugones

Classification

A34800 Drugs and pesticides
C10000 Biotechnology
D22100 Microbiology

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