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Research

Role of the secretome of Neisseria meningitidis in infection and protection

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Title Role of the secretome of Neisseria meningitidis in infection and protection
Period 01 / 2008 - unknown
Status Current
Research number OND1326663
Data Supplier Website ZonMw

Abstract

In the proposed project we intend to determine the function of the secreted proteins of N. meningitidis in colonization and infection and to evaluate their vaccine potential. Specifically, we intend to (i) identify the secretome of N. meningitidis and determine whether there are differences between the secretomes of isolates from carriers and from patients, (ii) establish whether these secreted proteins are expressed in vivo, (iii) elucidate the function of the secreted proteins and identify their host-cell targets, (iv) determine the occurrence and the relevance of gene conversion in the host-target specificity of secreted proteins, (v) determine whether the secreted proteins play an essential role in colonization and infection, and (vi) determine whether secretome-specific antibodies are bactericidal or block the function of these proteins.

Related organisations

Related people

Project leader Dr. A.J.W. van Alphen
Project leader Dr. A. van der Ende
Project leader Prof.dr. J.P.M. Tommassen

Classification

D21800 Immunology, serology
D23110 Infections, parasitology

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