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Excitability scaling in cognitive neuronal networks

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Titel Excitability scaling in cognitive neuronal networks
Looptijd 01 / 2006 - onbekend
Status Lopend
URL http://research.csca.nl/portal/site/CSCA-research/page/aaa5072b-d2eb-4a14-80d6-d1d072696b70
Onderzoeknummer OND1327680
Leverancier gegevens Website CSCA

Samenvatting (EN)

Plasticity and adaptation as occur in learning and some forms of disease could shift neurons outside their working range. We are investigating the functional and molecular properties of homeostatic control mechanisms that stabilize neuronal excitability. We study scaling mechanisms at the single cell and at the network level. The involvement of Ca2+ dynamics in the process, the role of oscillations and memory consolidation are evaluated. Furthermore we investigate scaling deregulation in the diseased brain, particularly in epileptogenesis. The neurophysiological experiments are supported by mathematical and computational modeling.

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Projectleider Prof.dr. W.J. Wadman

Classificatie

D23230 Neurologie, KNO , oogheelkunde

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