Perinatal motor function loss in human spina bifida aperta


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Title Perinatal motor function loss in human spina bifida aperta
Period 01 / 2008 - 06 / 2012
Status Completed
Dissertation Yes
Research number OND1327786
Data Supplier Website BCN


We studied the initiation and evolvement of segmental neuromuscular damage in children with myelomeningocele, the severe variant of a congenital neural tube defect or spina bifida aperta (SBA). Therefore, we measured muscle ultrasound density (MUD) in association with leg motor function loss both before and after birth. Results confirm the existence of two different impacts upon the segmental neurological leg-condition: 1. congenital damage as a direct consequence of the MMC, and 2. delayed, perinatal damage by secondary spinal trauma. The results indicating delivery-related spinal segmental haemorrhages located near persistent lower motor neurons, might explain the early neonatal disappearance of leg movements. This secondary perinatal segmental spinal damage, superimposed upon the congenital MMC, is hypothetically referred to as the second-hit of spinal damage. During the first year of life, the evolution of SBA leg MUD alterations reflects the impact of both congenital and second-hit spinal damage upon leg muscle integrity. Afterwards (1-18 years) leg-MUD parameters reflect a stabilised neuromuscular leg condition (i.e. completion of second-hit damage). Fetal closure of the MMC might protect aberrant blood vessels from bleeding and preserve neurological function. We found that fetal endoscopic surgery is associated with better spinal neuroprotection than neonatal surgery, but this is at the cost of iatrogenic morbidity for mother and child. Before considering clinical implementation of fetal MMC treatment as standard care, the frequency and impact of these complications should be reduced and investigated in larger study groups over a longer period of time.

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Supervisor Prof.dr. O.F. Brouwer
Doctoral/PhD student Dr. R.J. Verbeek


D23361 Neonatology

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