KNAW

Research

Deja Vu - Reja Vu; On knowledge-based approaches linking ligand and target...

Pagina-navigatie:


Update content


Title Deja Vu - Reja Vu; On knowledge-based approaches linking ligand and target information to bioactivity
Period 10 / 2007 - 01 / 2013
Status Completed
Dissertation Yes
Research number OND1328560
Data Supplier Website LACDR

Abstract

My project focuses on the development of proteochemometric modeling. In essence this relatively new technique allows for the creation of advanced structure-activity relations based on ligand information, protein information and mutual dependencies. It can therefore map structure activity relations between a series of compounds and a series of proteins including pair specific interaction data. Proteochemometric modeling can effectively separate chance correlations from real structure activity correlations when using very large datasets. Developing this technique and characterizing its advantages and possible shortcomings is the aim of my work at Medicinal Chemistry.

Related organisations

Related people

Supervisor Prof.dr. A.P. IJzerman
Supervisor Prof.dr. H.W. van Vlijmen
Doctoral/PhD student Dr. G.J.P. van Westen

Go to page top
Go back to contents
Go back to site navigation