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Modeling of the influence of age-related changes on the pharmacokinetics...

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Wijzig Onderzoekgegevens

Titel	Modeling of the influence of age-related changes on the pharmacokinetics and pharmacodynamics of drugs; Cytochrome P-450 3A metabolism and GABA A receptor function
Looptijd	01 / 2008 - onbekend
Status	Lopend
Dissertatie	Ja
Onderzoeknummer	OND1328583
Leverancier gegevens	Website LACDR

Samenvatting (EN)

The aim of this project is to develop model-based approach for regimen adjustments for the paediatric population, which account for developmental changes in drug exposure and response. Specific focus will be on Cytochrome P-450 3A metabolism and GABA A receptor function.

Betrokken organisaties

Penvoerder	Leiden / Amsterdam Center for Drug Research - LACDR (UL)
Financier	Top Institute Pharma - TI Pharma

Betrokken personen

Promotor	Prof.dr. M. Danhof
Promotor	Prof.dr. D. Tibboel
Co-promotor	Prof.dr. C.A.J. Knibbe
Promovendus	I. Ince (M.Sc.)

Classificatie

D23340	Biofarmaceutische wetenschappen, toxicologie
D23362	Kindergeneeskunde