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Female sexual dysfunction: Mechanisms and models

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Title Female sexual dysfunction: Mechanisms and models
Period 01 / 2008 - unknown
Status Completed
Research number OND1328679
Data Supplier Website Rudolf Magnus Instituut

Abstract

Aim of Project. The overall aim of the project is to develop an animal model in the female rat that reflects aspects of motivation (libido) and performance in sexual behavior and that are sensitive to pharmacological and hormonal manipulation Summary of research project. Female Sexual Disorders (FSD) affect a considerable percentage of women in Wsetern societies (see for review: Agmo et al. 2004a). One of the most prevalent of these disorders is 'Hypoactive sexual desire disorder (DSM-IV, 1995), characterized by 'persistently or recurrently deficient or absent sexual fantasies and desire for sexual activity'. The animal research into models for sexual desire is extremely limited although some research groups seem to have started research into this area. Agmo (1999; 2003) developed a theory equating sexual incentive motivation in female rats as equivalent to sexual desire. Incentive motivation can be seen as the intensity of approach behaviors, thus the approach towards a sexual stimulus. In previous research we investigated whether hormonally primed (in behavioral estrus) female rats displayed sexual endophenotypes. We were able to show in female Wistar rats that some females had stable low incentive to visit sexually active males, whereas other either displayed moderate to very high incentives to such males. We hypothetize that the 'low motivated' females model human FSD whereas the other categories model normal to hypersexual behavior. Approach to the research aims. * The overall aim of the project is to develop animal models in the female rat that reflect aspects of motivation (libido) and performance and that are sensitive to pharmacological and hormonal manipulation * Key objective 1: develop endophenotypic female models in rats with regard to their sexual drive or motivation * Key objective 2: test several drugs, hormones and combinations in these endophenotypic females * Key objective 3: Which brain and spinal cord mechanisms modulate these (abnormal) mechanisms involved in FSD

Related organisations

Related people

Researcher Dr. R.S. Oosting
Project leader Prof.dr. B. Olivier

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