| We have developed a method to measure endogenous glucose production (EGP) and hepatic insulin sensitivity in chronically hyper-, hypo- or euthyroid rats using stable isotopes. Thyrotoxicosis increases EGP and decreases hepatic insulin sensitivity. We now study effects of icv thyroid hormone administration We have started to study the in vivo generation and metabolic effects of T1AM, which is a member of a previously unknown class of thyronamines with a strong ability to antagonize thyroid hormone action (collaboration with Dr D Grandy) We have found a remarkable hepatic insulin resistance in antipsychotic naïve patients with first-episode schizophrenia. Since this study was controlled for abdominal fat mass, the results suggest a direct link between insulin resistance and schizophrenia We have identified the distribution and co-localization of the enzyme 11beta-HSD (type 1 and 2) in human hypothalamus and anterior pituitary using double-immunocytochemistry and confocal laser-scanning microscopy (collaboration with Dr P Stewart) In 2006, we have developed a database and research protocol for outpatients with pituitary insufficiency, with the ultimate goal to develop intervention studies aimed at improving quality of life We have further characterized and published the relationship between the effects of inflammation, food restriction and adipokines on thyroid hormone-related gene expression in the mouse hypothalamus and pituitary gland |
