The circulation, ventilation and ethics during multiple organ failure


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Title The circulation, ventilation and ethics during multiple organ failure
Period 01 / 2009 - unknown
Status Current
Research number OND1333095
Data Supplier Website Coeur


Critical illness often results in multiple organ failure. Sepsis is a common source and the syndrome affects the circulation and ventilation among other vital organ functions. The research around this typical intense care syndrome is thus programmed around these topics, as can be deducted from the individual projects enumerated below. Research on the circulation in the syndrome focuses on peripheral perfusion, among others. New techniques, like side stream dark field (SDF), laser speckle imaging and near-infrared spectroscopy (NIRS) have been studied for assessing microvascular perfusion in septic patients. In order to minimize inflammatory response in mechanically ventilated septic patients, a new lung monitoring device (Electrical Impedance Tomography) is used to optimize ventilator settings. Ultimately, the syndrome can be intractable, raising ethical issues on end-of life decisions.

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Project leader Prof.dr. J. Bakker
Project leader Dr. J. van Bommel
Project leader Dr. D.A.M.P.J. Gommers
Project leader Prof.dr. A.B.J. Groeneveld
Project leader C. Ince
Project leader Dr. E. Kompanje

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