| Insulin resistance is associated with various chronic diseases like diabetes mellitus type 2, metabolic syndrome, some forms of cancer, neurological diseases like Alzheimer disease, but also aging. The factors involved in the development of insulin resistance are not clear. UMCG Medical Biomics have developed a new proteomic method, called CILAIR (Comparison of Isotope Labeled Amino acid Incorporation Rates)(MS in preparation) which can be used to monitor the effect of hormones (insulin) on up and down regulation of proteins in tissues. This method will be applied to study insulin resistance. One of the cellular functions associated with insulin resistance and oxidative stress is the mitochondrial function. The UMCG is currently analyzing the mitochondrial proteome in the frame work of a current TI Pharma project and the effect of anti-oxidants. |
