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SAFE FOODS

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Title	SAFE FOODS
Period	01 / 2004 - unknown
Status	Completed
Research number	OND1334864

Abstract

The aim of this project is to establish an electronic platform (E-platform) of probabilistic intake calculation software and residue and food consumption databases of five different countries. This should result in a more harmonised risk assessment practice in Europe.
In this project all codes relevant for the food consumption and the residue databases of the five different countries were harmonised towards a classification system of the CODEX. Also the structure of the data collection was harmonised and data of the five different countries were stored in MS Access databases. A successful trial has been performed regarding data retrieval via the Internet from a computer (server) at the institutes at which the consumption and/or residue data are stored. The retrieved data were linked to the probabilistic software MCRA (Monte Carlo Risk Assessment) which is uploaded on a server in Wageningen. In this way institutes can control the access to their own data. For performance reasons all data were then sent to Wageningen.
In five different countries intake calculations were performed for pesticides (and other residues and contaminants) by using the harmonised databases per country. A second pan-European calculation was performed but now with a residue database in which all residue data from the five countries was pooled.
A third calculation was performed with similar age groups per country, because some of the differences in intake could be explained by an age effect. This first example of pan-European exposure modelling resulted in comparable results per country and is very useful in international risk assessment. Differences in the level of intake between countries were explained as a consequence of differences in consumption patterns and/or differences in monitoring practices per country.
A second aim of this project was to integrate probabilistic exposure modelling with probabilistic effect modelling. This has resulted in the IPRA (Integrated Probabilistic Risk Assessment) software. With this software calculations were performed for situations in which combined exposure to different chemicals occurs. This IPRA software and also the E-platform contribute to more knowledge regarding multidimensional exposure assessment

Abstract (NL)

Doel:
De doelstelling van WP3 SAFE FOODS zijn driedeling:
- Harmoniseren van databanken in vijf verschillende Europese landen en het koppelen van databanken aan probabilistische software om daarmee integrale innamenberekeningen te kunnen uitvoeren via Internet.
- Het integreren van probabilistische modellen in de toxicologische effect metingen met probabilistische modellen van de innamenberekeningen.
- Het integrale probabilistische model toepassen op een aantal berekeningen naar gecombineerde blootstelling.

Resultaten:
Het resultaat bestaat uit de volgende onderdelen:
· Er is een E-platform (elektronisch platform) waarbij MCRA (Monte Carlo Risk Assessment) gekoppeld is aan Zweedse, Italiaanse, Tsjechische, Nederlandse en Deense consumptie en residu data. Het E-platform werkt.
· Er is software ontwikkeld (IPRA (Integrated Probabilistic Risk Assessment) waarmee de probabilistische innamenberekeningen geïntegreerd kunnen worden met probabilistische toxicologische effectmetingen. IPRA is in gebruik in de vijf genoemde landen.
· Circa 8 wetenschappelijke papers in draft.

Publicaties bij dit project zijn beschikbaar via deze Link

Related organisations

Secretariat	RIKILT - Institute of Food Safety (WUR)
Financier	Department of Knowledge (EL&I)

Related people

Researcher	Dr.ir. P.E. Boon
Project leader	Ir. J.D. van Klaveren

Related research (upper level)

Program	KB-06-003 Muti-dimensional exposure

Classification

A71000	Nutrition
D21100	Bioinformatics, biomathematics, biomechanics