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Direct visualization of homology search and strand invasion in homologous repair

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Titel Direct visualization of homology search and strand invasion in homologous repair
Looptijd 06 / 2008 - 06 / 2012
Status Lopend
Dissertatie Ja
Onderzoeknummer OND1336178
Leverancier gegevens NWO

Samenvatting (EN)

Homologous repair is an essential mechanism responsible for repairing double-stranded breaks in DNA. How homologous sequences are found and invaded remains unresolved. I propose a novel approach to visualize this central event of repair at the single-molecule level, in real-time.

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