LifeSpan is an EU funded Network of Excellence. LifeSpan integrates research into development and ageing. The overall aim of the network is to establish the relationship between early-life events, and late-life survival, and health, and to identify the mechanisms that underpin this relationship. In LifeSpan we will move to and from between observations in humans and experiments in (in)vertebrate models, to test effects detected in one species in the context of candidate longevity mechanisms in the others. The LifeSpan consortium consists of the leading European laboratories that are crucial to studying mechanisms of ageing and development, and their interplay.