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Inhoudsstoffen Brassicae

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Titel Inhoudsstoffen Brassicae
Looptijd 01 / 2008 - 12 / 2010
Status Afgesloten
Onderzoeknummer OND1337220

Samenvatting

Doel
Het project richt zich op inventarisering van antikanker inhoudsstoffen (o.a. Organo-Selenium verbindingen en glucosinolaten) in het te consumeren weefsel in verschillende plantstadia van Brassica rapa en B. oleracea gewassen. De basis voor de selectie van geteste inhoudsstoffen zijn de metabolietprofielen; de geïdentificeerde stoffen worden vervolgens getest in humane kanker cellen.

Resultaten
Flavonoids are a class of plant secondary metabolites with important functions in plant protection to different stress types, including protection against UV light, pathogen resistance, etc. Apart from the important role in the plant, several flavonoids have been reported to have a positive effect on health. Different flavonoids have been correlated with cancer prevention but neither the bioactive doses nor the mechanism of action of these compounds have been well reported so far. In this project we identified several flavonoids that induce apoptosis of different cancer cell lines: quercitin, myricitin, fisetin, wogonin, kaempferol and resveratrol (stilbene). Quercitin showed the strongest effect among the compounds tested. Furthermore, combinatorial effects with cancer selective factors have been tested and quercitin revealed to synergise with TRAIL.

Publicaties bij dit project zijn beschikbaar via deze Link

Samenvatting (EN)

Flavonoids are a class of plant secondary metabolites with important functions in plant protection to different stress types, including protection against UV light, pathogen resistance, etc. Apart from the important role in the plant, several flavonoids have been reported to have a positive effect on health. Different flavonoids have been correlated with cancer prevention but neither the bioactive doses nor the mechanism of action of these compounds have been well reported so far. In this project we identified several flavonoids that induce apoptosis of different cancer cell lines: quercitin, myricitin, fisetin, wogonin, kaempferol and resveratrol (stilbene). Quercitin showed the strongest effect among the compounds tested. Furthermore, combinatorial effects with cancer selective factors have been tested and quercitin revealed to synergise with TRAIL.

Betrokken organisaties

Betrokken personen

Projectleider Dr. L.M. Trindade

Bovenliggende onderzoeksactiviteit(en)

Classificatie

A70000 Volksgezondheid en gezondheidszorg
A71000 Voeding

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