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The effects of supplementation of zinc and other micronutrients on...

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Title The effects of supplementation of zinc and other micronutrients on cellular and serological indicators of immunity against malaria in Tanzanian children
Period 01 / 2005 - unknown
Status Completed
Dissertation Yes
Research number OND1337685

Abstract

Introduction:
Evidence from community-based randomised controlled trials shows that zinc supplementation can result in dramatic reductions in morbidity from malaria and improved growth in some populations of children.The study aims at determining the potential effects of supplementation of zinc and other micronutrients on the cellular and serological indicators of immunity against malaria in Tanzanian children.

Results:
This study is expected to provide new, better and conclusive evidence on the efficacy of zinc supplementation on malaria, specifically on cellular or soluble mediators of immunity. By measuring effects on status for other micronutrients, our study may provide new evidence of deficiencies that have been little studied in children but that are often considered as possible public health problems. This will also contribute to international efforts to develop and evaluate innovative supplementation vehicles suitable for young children in tropical environments.

Articles: Publications
1) Mbugi et al. Multiplicity of infections and level of recrudescence in P.falciparum malaria. Afr.J.Biotechnol. 2006 Sept;5(18)1655-1662
2) Mbugi et al: Drug resistance to Sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum malaria in Tanzania. Malar J. 2006 Oct;5:94
3) Veenemans J, Andango PE, Mbugi EV: Thalassemia Protects Anemia with Asymptomatic Malaria (JID, July 2008)

Related organisations

Related people

Supervisor Prof.dr.ir. H.F.J. Savelkoul
Co-supervisor Dr. J.C.M. Verhoef
Project leader E.V. Mbugi
Doctoral/PhD student E.V. Mbugi

Related research (upper level)

Classification

C20000 Development studies
D21500 Histology, cell biology
D21800 Immunology, serology

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