KNAW

Research

Using high-throughput screening of chemical libraries to identify factors...

Pagina-navigatie:


Update content


Title Using high-throughput screening of chemical libraries to identify factors involved in cross-presentation
Period 12 / 2009 - unknown
Status Current
Research number OND1338761
Data Supplier NWO

Abstract

Anti-tumoral and anti-viral immune responses display a similar achilles heel: they lack an efficient cytotoxic CD8+ T cell response, and this can be fatal in many situations. Such an immune response requires the presentation of tumor or viral antigen in the context of Major Histocompatibility Class I by dendritic cells (DCs) to CD8+ T cells through a specialised process called cross-presentation. However, the cellular and molecular mechanisms underlying this process remain poorly characterized. A better understanding of cross-presentation and the improvement of its efficiency is therefore an issue on the forefront of immunological and pharmaceutical research. The aim of this study is to provide a better knowledge of the process of crosspresentation and to potentially design new effective anti-tumoral and viral immunotherapies by targeting this process. To this end, I will screen the effects of a collection of approx 4,000 drugs on cross-presentation by DCs. Data from these studies will provide insight into the basic mechanisms of cross-presentation, and will potentially contribute to the discovery of new drugs able to regulate this process.

Related organisations

Related people

Project leader Dr. C.S. Sadaka

Go to page top
Go back to contents
Go back to site navigation