Identification of molecular mechanisms underlying metabolic setpoints


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Title Identification of molecular mechanisms underlying metabolic setpoints
Period 10 / 2009 - 12 / 2013
Status Current
Dissertation Yes
Research number OND1339821


Obesity is one of the five major health problems in modern society, mainly due to its possible consequences. A common problem is weight regain following acute weight loss, maintenance of the lower body weight seems more difficult. This could be explained by the set point theory, in which the adipose tissue mass signals the brain to protect its previous adiposity level. How this is exactly regulated is still unknown. Therefore we aim to gain insight in metabolic adaptations of the body to different dietary patterns. Characterization of these metabolic changes (physiological and molecular) will be performed with the help of an animal intervention study.

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Supervisor J. Keijer
Co-supervisor E.M. van Schothorst
Doctoral/PhD student F.P.M. Hoevenaars (MSc)

Related research (upper level)


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D21700 Physiology
D22100 Microbiology

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