Identification of molecular mechanisms underlying metabolic setpoints
10 / 2009 - 12 / 2013
Obesity is one of the five major health problems in modern society, mainly due to its possible consequences. A common problem is weight regain following acute weight loss, maintenance of the lower body weight seems more difficult. This could be explained by the set point theory, in which the adipose tissue mass signals the brain to protect its previous adiposity level. How this is exactly regulated is still unknown. Therefore we aim to gain insight in metabolic adaptations of the body to different dietary patterns. Characterization of these metabolic changes (physiological and molecular) will be performed with the help of an animal intervention study.