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Perseveration in the development of Obsessive Compulsive Disorder

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Titel Perseveration in the development of Obsessive Compulsive Disorder
Looptijd 06 / 2011 - 06 / 2015
Status Lopend
Dissertatie Ja
Onderzoeknummer OND1340469
Leverancier gegevens NWO

Samenvatting (EN)

Patients with Obsessive Compulsive Disorder (OCD) try to reduce obsessive uncertainty by 'perseverative compulsions', like checking repetitively. Earlier studies have found that compulsive perseveration paradoxically enhances uncertainty. This helps to explain why OCD persists. Here, we will examine paradoxical effects of perseveration in the development of OCD. We will test whether, relative to others, OCD patients are generally inclined to respond to uncertainty by perseveration, whether the same holds true for first-degree relatives of OCD-patients, whether in the natural course of OCD perseveration precedes clinical uncertainty, and whether the development of clinical uncertainty can be prevented by abstaining from perseveration.

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