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Cardiolipins and Respiratory Chain Supercomplexes

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Title Cardiolipins and Respiratory Chain Supercomplexes
Period 10 / 2010 - 10 / 2011
Status Current
Research number OND1341457
Data Supplier NWO

Abstract

In this DCCP proposal, we propose a number of large scale coarse-grained molecular dynamics simulations to reveal the structure and dynamics of respiratory chain supercomplexes formed in mitochondrial membranes. Our main aims are to predict the interfaces formed between the various complexes and the role of cardiolipins herein. The sheer size of these systems warrants the use of large supercomputer facilities.

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Project leader Prof.dr. S.-J. Marrink

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