Functional markers for cognitive disorders: Dementia (B)
12 / 2010 - 11 / 2014
Cognitive functions, including memory and language are increasingly understood not to be localised in one specific brain area, but rather in networks between a multitude of brain cells. In this study, we investigate changes in connectivity between brain areas and brain structure in dementia (Alzheimer's disease, frontotemporal lobar degeneration) in comparison with healthy controls. Moreover, we study how functional connectivity is related to changes in anatomical connectivity, and how connectivity and brain structure change over a two-year period. Partial plan B focuses on changes in brain structure. We will include 40 patients with AD, 40 patients with FTLD and 40 controls. All patients will be scanned at baseline and two-year follow-up on a 3 Tesla scanner.