Stroke: risk factors and etiology, prognosis and treatment
01 / 2010 - unknown
Stroke is a heterogeneous disease; it comprises ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage. Stroke is a high ranking cause of death and the most common cause of acquired disability in The Netherlands and Western Europe. Causes of disability include motor function and disturbances of language, memory and cognition. Etiologic studies include genetics (Metabochip), hemostasis (von Willebrand factor, fibrinogen), glucose metabolism, cardioembolic disorders (SURTAVI), and carotid plaque morphology (PARISK) Intervention studies include a series of multicenter RCT s of the effect of prevention of high body temperature and fever (PAIS). Also, we conduct a large national multicenter study of the effect of intra-arterial treatment for acute ischemic stroke (MR CLEAN). Moreover, we evaluate early cognitive linguistic treatment of aphasia in a series of multicenter RCT s (RATS) Prognostic studies include prediction of outcome after stroke, recurrent vascular events and vascular cognitive impairment, and functional imaging (FIAT) and outcome (SPEAK) of aphasia caused by stroke in large patient-cohorts. Data for genetic, prognostic and etiologic studies are derived from the Erasmus Stroke Study, an ongoing hospital based registry, and from the Rotterdam study, a large population based cohort study.