Breeding for broad-spectrum resistance in Solanaceous crops: identifying...


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Title Breeding for broad-spectrum resistance in Solanaceous crops: identifying and exploring regulatory nuclear proteins connecting R gene specific resistance and basal defence
Period 10 / 2008 - unknown
Status Current
Research number OND1342383


To defend themselves, plants have evolved a surveillance system consisting of single dominant resistance (R) genes and a more generic pathogen associated molecular pattern (PAMP) recognition system. Recently, it has been shown that R proteins are transported into the nucleus and that R gene mediated resistance and PAMP triggered basal defence can be linked by the interaction of R proteins with WRKY transcription factors in the nucleus. Overexpression of the WRKY transcription factors suppresses R gene specific resistance to powdery mildew and silencing of the WRKY transcription factors resulted in enhanced basal defense. Thus, the two pathways converge in the nucleus and the R gene triggered pathway seems very short, which makes the nucleus the centre court for innovative disease resistance breeding. The objective of this project is to use R proteins as baits to identify for Solanaceous crops a set of regulatory proteins, most probably transcription factors, from the nucleus that can be explored as leads to select allelic variants that confer enhanced basal disease resistance to a wide range of pathogens.

Related organisations

Other involved organisations

De Ruiter Seeds R&D NL BV
Enza Zaden Research and Development BV

Related people

Researcher J. Bakker
Researcher A. Goverse
Researcher Dr. J. Roosien
Researcher Ir. E. Slootweg

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