Pregnancy in Congenital Heart Disease II (Zahara II)
05 / 2008 - 05 / 2012
The ZAHARA II study is a prospective international multi-centre cohort study. The objectives of the study are to prospectively investigate the changes in and the relation between cardiovascular parameters and uteroplacental fow parameters during/after pregnancy in women with congenital heart disease (CHD) and to compare these changes with age/parity-matched healthy controls We will relate the cardiovascular and uteroplacental fow parameters with the occurrence of obstetric and offspring complications All pregnant women with CHD and with a pregnancy duration of < 20 weeks presenting in one of the participating centres are included in the study We plan to include 200 pregnant women with CHD and 60 healthy pregnant women Serial (20, 32 weeks of pregnancy, 1-year postpartum) standardised echocardiograms are performed. Foetal growth and utero-placental perfusion (e.g. fow velocity measurements of uterine and umbilical artery) are studied by Doppler ultrasound evaluations (20 weeks and 32 weeks Neurohumoral parameters (Nt-pro-BNP) are assessed during/after pregnancy Exercise testing is be performed 1-year postpartum in patients who have undergone this test less than 2 years before pregnancy.