Hollander, den J.G. (Jan)Mouton, J.W. (Johan)Bakker-Woudenberg, I.A.J.M. (Irma)Vleggaar, F.P. (Frank)Goor, van M.P.J.Verbrugh, H.A. (Henri)Comparative StudyAcetyltransferases/*pharmacologyBacteria/drug effects/*metabolismGentamicins/metabolismMicrobial Sensitivity Tests/*methodsTobramycin/metabolismAnti-Bacterial Agents/*metabolismhttp://hdl.handle.net/1765/8625enjournalArticle0066-4804To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.1996-01-01 0066-4804 urn:NBN:nl:ui:15-1765/8625