Geleijnse, J.M. (Marianne)Launer, L.J. (Lenore)Kuip, van der D.A. (Deirdre)Witteman, J.C.M. (Jacqueline)Hofman, A. (Albert)MaleDose-Response Relationship, DrugAgedFemaleHumansMiddle agedResearch Support, Non-U.S. Gov'tIncidenceLongitudinal StudiesNetherlandsRisk AssessmentDiet*Kaempferols*TeaFlavonoids/*administration & dosage/pharmacologyMyocardial Infarction/epidemiology/etiology/mortality/*prevention & controlQuercetin/administration & dosage/*analogs & derivatives/pharmacologyhttp://hdl.handle.net/1765/9892enjournalArticle0002-9165BACKGROUND: Dietary flavonoids may protect against cardiovascular disease, but evidence is still conflicting. Tea is the major source of flavonoids in Western populations. OBJECTIVE: The association of tea and flavonoid intake with incident myocardial infarction was examined in the general Dutch population. DESIGN: A longitudinal analysis was performed with the use of data from the Rotterdam Study-a population-based study of men and women aged >or=55 y. Diet was assessed at baseline (1990-1993) with a validated semiquantitative food-frequency questionnaire. The analysis included 4807 subjects with no history of myocardial infarction, who were followed until 31 December 1997. Data were analyzed in a Cox regression model, with adjustment for age, sex, body mass index, smoking status, pack-years of cigarette smoking, education level, and daily intakes of alcohol, coffee, polyunsaturated fat, saturated fat, fiber, vitamin E, and total energy. RESULTS: During 5.6 y of follow-up, a total of 146 first myocardial infarctions occurred, 30 of which were fatal. The relative risk (RR) of incident myocardial infarction was lower in tea drinkers with a daily intake >375 mL (RR: 0.57; 95% CI: 0.33, 0.98) than in nontea drinkers. The inverse association with tea drinking was stronger for fatal events (0.30; 0.09, 0.94) than for nonfatal events (0.68; 0.37, 1.26). The intake of dietary flavonoids (quercetin + kaempferol + myricetin) was significantly inversely associated only with fatal myocardial infarction (0.35; 0.13, 0.98) in upper compared with lower tertiles of intake. CONCLUSIONS: An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease.2002-01-01 0002-9165 urn:NBN:nl:ui:15-1765/9892